논문검색
Author Young Don Joo, M.D. and Chang Hak Sohn, M.D.
Place of duty Department of Internal Medicine, Inje University College of Medicine, Pusan, Korea
Title Clinical Significance of p53, P-glycoprotein, and Glutathione S transferase-π in Advanced Non-Small Cell Lung Cancer
Publicationinfo Cancer Research and Treatment 2002 Feb; 034(01): 34-40.
Key_word Non-small cell lung cancer, p53, P- glycoprotein, Glutathione S transferase-π, Immunohistochemical stain
Full-Text
Abstract Purpose: A retrospective study was performed o define the clninical significance of p53, P-glycoprotein (Pgp), and Glutathione S transferase-π (GST-π) immunohistochemical (IHC) expression in advanced non-small cell lung cancer (NSCLC).

Materials and Methods: We reviewed fifty seven patients with advanced NSCLC who had undergone surgical resection or bronchoscopic biopsy between March 1997 and March 1999. IHC staining for p53, GST-π, and Pgp was performed using formalin-fixed, paraffin- embedded specimens of the fifty seven patients.

Results: The IHC expression rate was 63% for p53, 28% for Pgp, and 53% for GST-π, respectively. The median survival of the fifty seven patients was 45 weeks and the response rate was 38.6% (partial response, 22/57). The chemotherapy response and median survival of the p53 negative group (57% and 61 weeks) were better than those demonstrated by the p53 positive group (28%

and 21 weeks) (p＜0.05). Additionally, the GST-π negative group showed a greater improvement of survival and response rate than the positive group (p＜0.05). Pgp expression status appeared to have no significant differential effect on chemotherapy response and survival.

Conclusion: These results suggest that immunohistochemical staining of p53 and GST-π may be useful in predicting the response to chemotherapy as well as survival in advanced NSCLC. However, this study is limited by its retrospective nature and the small numbers of tumors studied from a heterogenous group of patients. (Cancer Research and Treatment 2002;34:34⁣40)

저 자 주영돈, 손창학